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5.01 - Arrival

• Precious by Depeche Mode
  plays at the end of the episode
  

5.02 - Mortal

• A message by Coldplay
  plays at the end of the episode
  

5.03 - Hidden

• Breathe (2 a.m.) by Anna Nalick
  plays when Clark wakes up next to Lana
  
• Collide by Dishwalla
  plays when Clark comes back home to find his parents and is reunited with Lana
  
• Supernatural by Wild Whirled
  
• Disappearing world by David Gray
  plays during the final scene with Clark and Chloe
  

5.04 - Aqua

• All the money or the simple life honey by The Dandy Warhols
  plays at the beginning of the episode
  
• Waiting for your letter by Cary Brothers
  
• Everyday is like the weekend by Amy Ward
  

5.05 - Thirst

• Wikked lil' grrrls by Esthero
  
• Guiltless by Martin Grech
• Girls Attractive by Diamond Nights
  
• Bela Lugosi's dead by Bauhaus
  
• Abandoned by The Swear
  
• Set the grass on fire by Elysian Fields
  

5.06 - Exposed

• Cold hands (warm heart) by Brendan Benson
  
• Don't cha by The Pussycat Dolls
  
• All jacked up by Gretchen Wilson
  
• I'm human by Flashlight Brown
  

5.07 - Splinter

• Superman by Stereophonics
  
• Forget it by Breaking Benjamin
  
• Homeward angel by Moby
  

5.08 - Solitude

• Wicked game by HIM
  

5.09 - Lexmas

• That spirit of Christmas by Ray Charles
  
• Dance of the sugar plum fairy by Tchaikovsky

5.10 - Fanatic

• I want it all by Depeche Mode
  plays when Martha gets into the limo
  

5.11 - Lockdown
No music in this episode

5.12 - Reckoning

• You're beautiful by James Blunt
  plays during both Clark & Lana loft scenes
  
• I grieve by Peter Gabriel
  plays during Jonathan's funeral at the very end of the episode
  

5.13 - Vengeance
No music in this episode

5.14 - Tomb
No music in this episode

5.15 - Cyborg

• Life after love by Colored Shadows
  plays when Lana is in the car
  
• Casta diva (from Norma) by Bellini
  

5.16 - Hypnotic

• Almost honest by Josh Kelley
  
• Dirty little secret by the All-American Rejects
  

5.17 - Void
No music in this episode

5.18 - Fragile
No music in this episode

5.19 - Mercy
No music in this episode

5.20 - Fade
No music in this episode

5.21 - Oracle
No music in this episode

5.22 - Vessel
No music in this episode